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Triamcinolone in corticosteroid-resistant asthma.

M D Peake, R M Cayton, P Howard

    British Journal of Diseases of the Chest
    |January 1, 1979
    PubMed
    Summary
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    Depot injections of triamcinolone acetonide improved chronic asthma control in many patients, reducing hospital admissions and showing sustained spirometry improvements over three years. Further controlled trials are recommended to confirm these findings.

    Area of Science:

    • Pulmonology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Chronic asthma management remains challenging, particularly for patients refractory to high-dose oral corticosteroids.
    • Triamcinolone acetonide, a corticosteroid, has been investigated for its long-term efficacy in asthma.
    • Uncontrolled asthma contributes to frequent hospitalizations and reduced quality of life.

    Purpose of the Study:

    • To evaluate the long-term effectiveness and safety of depot injections of triamcinolone acetonide in patients with chronic asthma.
    • To assess the impact of this treatment on asthma control, hospital admission rates, and pulmonary function.

    Main Methods:

    • An uncontrolled study involving 38 patients with chronic asthma.
    • Treatment administered via depot injections of triamcinolone acetonide for up to 4.5 years (mean 2.9 years).

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  • Assessment of asthma control, side effects, adrenal function, and spirometry (pulmonary function tests).

    • Main Results:

    • Approximately three-quarters of patients experienced improved asthma control.
    • A reduction in hospital admission incidence was observed.
    • Side effects were generally tolerable, with only moderate depression of adrenal function.
    • Spirometry demonstrated continued improvement for up to three years.

    Conclusions:

    • Depot triamcinolone acetonide injections appear to be a beneficial treatment option for a significant proportion of chronic asthma patients, including those with difficult-to-control disease.
    • The treatment demonstrated sustained efficacy and an acceptable safety profile.
    • A controlled trial is warranted to definitively establish the efficacy compared to alternative corticosteroid regimens or natural disease progression.