[Effect of morphine and its derivatives on the electric conductivity of artificial phospholipid membranes]

It has been shown that morphine, codeine, dionine and nalorphine do not change significantly the electroconductivity of bilayer lipid membranes (BLM) in the presence of potassium ions in the medium. Changes in BLM phospholipid composition, KC1 and opiate concentration in the medium, as well as the ratio between ionized and unionized forms of the narcotics do not affect the conductivity of lipid bilayers. A conclusion is made that morphine derivatives do not produce immediate effect on membrane potassium permeability.