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Plasma acetate concentrations during canine haemorrhagic shock
Scandinavian Journal of Clinical and Laboratory Investigation
|November 1, 1979
Summary
During hypovolemic shock in dogs, plasma acetate levels increased but did not contribute to metabolic acidosis. Pyruvate appears to be the primary source of acetate production.
Area of Science:
- Biochemistry
- Physiology
- Veterinary Medicine
Background:
- Hypovolemic shock can lead to significant metabolic disturbances.
- Understanding the role of various metabolites, such as acetate, is crucial in managing shock.
- Acetate metabolism during shock has not been fully elucidated.
Purpose of the Study:
- To investigate the changes in plasma acetate concentrations during induced hypovolemic shock in dogs.
- To determine the relationship between acetate, pyruvate, lactate, and acid-base parameters during shock.
- To identify potential substrates for acetate production in hypovolemic shock.
Main Methods:
- Five dogs underwent controlled bleeding to induce stable hypotension (mean arterial pressure of 30 mmHg).
- Blood samples were collected during bleeding, hypotension, and re-infusion.
- Concentrations of acetate, pyruvate, lactate, NEFA, and acid-base parameters were measured.
Main Results:
- Plasma acetate concentrations significantly increased during hypovolemic shock and re-infusion.
- A strong positive correlation was observed between blood pyruvate and plasma acetate levels.
- Acetate accumulation was minimal compared to lactate and did not contribute to metabolic acidosis.
Conclusions:
- Acetate accumulation during hypovolemic shock is modest and does not significantly contribute to acidosis.
- Pyruvate is likely the primary substrate for acetate production under these conditions.
- These findings provide insights into the metabolic response to shock in a canine model.