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A proposed hydrogen transfer function for cytochrome c.

J E Harrison

    Proceedings of the National Academy of Sciences of the United States of America
    |June 1, 1974
    PubMed
    Summary
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    This study proposes new mechanisms for cytochrome c oxidoreduction, highlighting its role in hydrogen transfer. The findings align with recent proposals regarding the transition state during cytochrome c reduction.

    Area of Science:

    • Biochemistry
    • Enzymology
    • Electron Transfer

    Background:

    • Cytochrome c plays a crucial role in cellular respiration as a key electron carrier.
    • Understanding the precise mechanism of cytochrome c oxidoreduction is vital for comprehending cellular energy production.
    • Existing models of cytochrome c function have limitations in fully explaining its catalytic cycle.

    Purpose of the Study:

    • To propose novel mechanistic pathways for cytochrome c oxidoreduction.
    • To investigate the role of hydrogen transfer in the catalytic cycle of cytochrome c.
    • To reconcile proposed mechanisms with established biochemical principles and recent findings.

    Main Methods:

    • Theoretical modeling of enzyme-catalyzed reactions.
    • Analysis of electron and proton transfer pathways.

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  • Comparison of proposed mechanisms with experimental data and existing literature.

    • Main Results:

    • New mechanisms for cytochrome c oxidoreduction are presented, differing from previous models.
    • The proposed mechanisms confirm cytochrome c's dual role as an electron acceptor and donor.
    • Evidence supports a catalytic role for the enzyme in hydrogen transfer during reduction.
    • The mechanism aligns with the proposal of a transition state analogous to ferricytochrome c(2).

    Conclusions:

    • Cytochrome c's function involves intricate hydrogen transfer processes.
    • The proposed mechanisms offer a refined understanding of cytochrome c's catalytic cycle.
    • Further research into the hydrogen transfer role of cytochrome c is warranted.