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Related Experiment Videos

Enhanced interferon response to murine leukemia virus by ascorbic acid.

B V Siegel

    Infection and Immunity
    |August 1, 1974
    PubMed
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    BALB/cJ mice supplemented with vitamin C (l-ascorbate) showed increased interferon levels when exposed to a leukemia virus. This suggests vitamin C may enhance immune responses to viral infections.

    Area of Science:

    • Immunology
    • Virology
    • Nutritional Science

    Background:

    • Interferon is a critical cytokine in the innate immune response against viral infections.
    • Ascorbate (vitamin C) is known for its antioxidant and immune-modulating properties.
    • Murine leukemia virus (MLV) is an oncoretrovirus that can infect mice.

    Purpose of the Study:

    • To investigate the effect of high-dose l-ascorbate supplementation on interferon production in mice stimulated with murine leukemia virus.

    Main Methods:

    • BALB/cJ mice were administered 250 mg% l-ascorbate in their drinking water.
    • Mice were subsequently stimulated with murine leukemia virus.
    • Circulating interferon levels were measured.

    Main Results:

    Related Experiment Videos

    • Mice receiving l-ascorbate exhibited augmented levels of circulating interferon compared to controls (implied).
    • This indicates a heightened interferon response in vitamin C-supplemented mice post-viral stimulation.

    Conclusions:

    • High-dose l-ascorbate supplementation may enhance the innate immune response, specifically interferon production, in BALB/cJ mice challenged with murine leukemia virus.
    • These findings suggest a potential role for vitamin C in bolstering antiviral immunity.