Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

293
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
293
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

668
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
668
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

287
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
287
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

979
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
979

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chondrocytes, Mesenchymal Stem Cells, and Their Combination in Articular Cartilage Regenerative Medicine.

Annals of biomedical engineering·2016
Same author

Experimental inoculation of domestic pigeons (Columbia livia) and zebra finches (Poephila guttata) with Neospora caninum tachyzoites.

International journal for parasitology·1999
Same author

Ingestion of Neospora caninum tissue cysts by Mustela species.

International journal for parasitology·1999
Same author

Repetitive abortion in Neospora-infected ewes.

Veterinary parasitology·1999
Same author

Real-time analysis of immunogen complex reaction kinetics using surface plasmon resonance.

Analytical biochemistry·1998
Same author

Dogs are definitive hosts of Neospora caninum.

International journal for parasitology·1998
Same journal

Large-Eddy Simulation of the FDA Benchmark Blood Pump: Validation Against Experiments and Implications for Turbulent Flow Mechanisms.

Artificial organs·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
06:45

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids

Published on: August 9, 2024

2.1K

A model enzymic extracorporeal detoxification system.

S S Sofer, R A Wills, B J Van Wie

    Artificial Organs
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel extracorporeal detoxification unit using a continuous blood centrifuge and immobilized enzymes to remove foreign chemicals. This innovative approach shows potential as an efficient artificial liver support device.

    More Related Videos

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
    08:59

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

    Published on: December 3, 2020

    8.7K
    Decellularization and Recellularization of Whole Livers
    09:24

    Decellularization and Recellularization of Whole Livers

    Published on: February 4, 2011

    22.6K

    Related Experiment Videos

    Last Updated: Mar 1, 2026

    Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
    06:45

    Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids

    Published on: August 9, 2024

    2.1K
    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
    08:59

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

    Published on: December 3, 2020

    8.7K
    Decellularization and Recellularization of Whole Livers
    09:24

    Decellularization and Recellularization of Whole Livers

    Published on: February 4, 2011

    22.6K

    Area of Science:

    • Biomedical Engineering
    • Toxicology
    • Biochemistry

    Background:

    • Foreign chemical removal from blood is crucial for detoxification.
    • Existing methods face challenges with toxin dilution and membrane adherence.
    • Hepatic assist devices aim to support or replace liver function.

    Purpose of the Study:

    • To evaluate a continuous, seal-less blood centrifuge as an extracorporeal detoxification unit.
    • To investigate the use of immobilized enzymes and cofactor regeneration for chemical detoxification.
    • To explore the potential of this system as a hepatic assist device.

    Main Methods:

    • Utilizing a continuous, seal-less blood centrifuge to process blood plasma.
    • Employing immobilized enzymes and a macromolecule-bound cofactor (NADPH) for chemical transformation.
    • Implementing a semipermeable membrane to retain the cofactor and facilitate reactions.
    • Incorporating a cofactor regeneration system using G-6-P and G-6-PD.
    • Separating plasma from interfering blood components (platelets, cells) via centrifugation.

    Main Results:

    • The device facilitates the reaction of drugs with cofactor and enzymes to form drug-oxides.
    • The centrifuge enhances detoxification by providing toxin-rich plasma, free of interfering blood components.
    • Membrane permeability is maintained by removing components that cause dilution or adherence.

    Conclusions:

    • The combination of a continuous centrifuge and enzymatic detoxification shows promise for removing foreign chemicals.
    • This system has the potential to function as an efficient hepatic assist device.
    • Further studies are warranted to validate its efficacy and safety in clinical applications.