Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement alterations in inflammatory bowel disease.

A M Lake, A E Stitzel, J R Urmson

    Gastroenterology
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis.

    Mucosal immunology·2017
    Same author

    Problems + Solutions.

    Postgraduate medicine·2016
    Same author

    Antigen uptake in the gut: immunologic implications.

    Immunology today·2014
    Same author

    The role of gut microbiota in programming the immune phenotype.

    Journal of developmental origins of health and disease·2013
    Same author

    Vaginal calculi in the dolphin.

    Journal of wildlife diseases·2013
    Same author

    Immune factors in breast milk and the development of atopic disease.

    Journal of pediatric gastroenterology and nutrition·2012

    Inflammatory bowel disease (IBD) patients show normal classical complement pathway activity but impaired alternative pathway function. These complement abnormalities, particularly in regional enteritis and ulcerative colitis, resolve with clinical remission.

    Area of Science:

    • Immunology
    • Gastroenterology
    • Complement System Biology

    Background:

    • Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis.
    • The complement system is crucial in innate immunity and inflammation.
    • Its role in IBD pathogenesis requires further elucidation.

    Purpose of the Study:

    • To prospectively evaluate complement system activity in newly diagnosed IBD patients before treatment.
    • To investigate potential differences in complement activation pathways between IBD subtypes and disease severity.

    Main Methods:

    • Prospective study of 32 newly diagnosed IBD patients.
    • Assessment of serum classical and alternative complement pathways.
    • Measurement of complement components (properdin, C3-C9) and functional assays, including cobra venom reaction.

    Related Experiment Videos

    Main Results:

    • Normal classical complement pathway activity observed in all patients.
    • Significant alternative complement pathway abnormalities detected, including reduced properdin and properdin convertase.
    • Diminished consumption of C3-C9 after cobra venom reaction, indicating impaired alternative pathway function.
    • Abnormalities were most pronounced in regional enteritis and ulcerative colitis with extraintestinal manifestations.

    Conclusions:

    • The alternative complement pathway is significantly implicated in the pathophysiology of newly diagnosed IBD.
    • Alternative pathway dysfunction is associated with specific IBD subtypes and disease complications.
    • Resolution of complement abnormalities correlates with clinical remission, suggesting a dynamic role in disease activity.