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Updated: May 5, 2026
07:27
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
Published on: October 21, 2017
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Summary
Perhexiline maleate, an anti-anginal drug, caused hepatitis in two patients. Liver damage included fatty changes and features resembling alcoholic hepatitis, with one patient showing severe hepatocyte atypia.
Area of Science:
- Hepatology
- Toxicology
- Pharmacology
Background:
- Perhexiline maleate is an anti-anginal medication.
- Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.
Observation:
- Two patients on perhexiline maleate developed hepatitis.
- Histological examination revealed mild to moderate fatty changes and hepatitis.
- Pathological features mimicked alcoholic hepatitis, including Mallory's hyaline-like material.
Findings:
- The observed Mallory's hyaline-like material showed a predominantly periportal distribution, differing from the typical centrilobular pattern in alcoholic hepatitis.
- One patient exhibited severe hepatocyte atypia, persisting for 10 weeks post-discontinuation.
- The second patient developed advanced hepatic fibrosis.
Implications:
- This case series highlights perhexiline maleate as a potential cause of DILI.
- The distinct histological pattern may aid in diagnosing drug-induced liver injury.
- Further investigation into the hepatotoxicity of perhexiline is warranted.
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