[Graph method of analyzing the stationary kinetics of polyenzyme systems]

Methods based on the graphical representation of relations between metabolites concentrations were worked out for the description and analysis of the steady-state kinetics of the multienzyme systems. The properties of graphics characterizing various steady-state regimens were investigated. Relations relevant to the analysis of regulatory phenomena were derived for the concentration of non-adjacent metabolites. Rules are presented for the kinetical description of multienzyme systems posessing external inputs and outputs. Certain branchings occuring in multienzyme systems were considered. The developed methods allow generalization concerning multisubstrate multiproduct reactions as well as systems containing regulatory enzymes with non-michaelian kinetics. It is suggested that the generalized methods may be helpful for the analysis of the metabolic regulation.