Effect of zinc on some biochemical indices of metabolism

The role of zinc in some metabolic functions in man was investigated in 14 healthy male volunteers with primarily high or low serum zinc. In all the subjects, results of laboratory tests reflecting blood picture, metabolism of carbohydrates, fats and proteins and thyroid function as well as serum calcium and phosphate levels varied within the normal range. Significant differences between the subjects classified by serum zinc were found in alpha1-globulins. Serm thyroxins, effective thyroxine ratio and the immunoglobulins IgA showed a tendency to lower levels in subjects with low serum zinc. Substitution with zinc sulphate resulted in an increase of alpha 1-globulins, serum thyroxine and effective thyroxine ratio, and a decrease of albumin. Other tests remained by the therapy. The results suggest that there is a relationship between zinc and some metabolic functions in healthy subjects without symptoms of zinc deficiency.