Synthesis of the sultam analog of 11-deoxy PGE2

As an extension of our work on the series of N-alkylmethanesulfonamidoheptanoic acids, we have prepared the cyclic-sulfonamide (sultam) analog of 11-deoxy PGE2. Although numerous publications have described the introduction of heteroatoms into the 5-membered ring of the prostaglandins, the cyclic-sulfonamides have remained a heretofore unexplored class. The synthetic scheme for the preparation of this unique PG analog is presented in this paper.