Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Burn sepsis and burn toxin.

M Allgöwer, K Städtler, G A Schoenenberger

    Annals of the Royal College of Surgeons of England
    |November 1, 1974
    PubMed
    Summary

    Researchers identified a burn toxin causing late mortality and morbidity after severe burns. This discovery aids in developing new immunization therapies for burn patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Delta sleep-inducing peptide (DSIP): EEG and motor activity in rabbits following intravenous administration.

    Neuroscience letters·2009
    Same author

    Skin toxicity induced by wet heat.

    Burns : journal of the International Society for Burn Injuries·2003
    Same author

    Burning the largest immune organ.

    Burns : journal of the International Society for Burn Injuries·1995
    Same author

    Survival in major burn injuries treated by one bathing in cerium nitrate.

    Burns : journal of the International Society for Burn Injuries·1992
    Same author

    The floating shoulder: ipsilateral clavicle and scapular neck fractures.

    The Journal of bone and joint surgery. British volume·1992
    Same author

    [Relations of Theodor Kocher with the "International Society of Surgery". His role as the 1st congress president].

    Gesnerus·1992

    Area of Science:

    • Biomedical research
    • Toxicology
    • Immunology

    Background:

    • Burn disease, characterized by late mortality and morbidity, poses significant clinical challenges.
    • Understanding the underlying mechanisms of burn disease is crucial for effective treatment.

    Purpose of the Study:

    • To describe key research steps over 20 years investigating burn disease.
    • To isolate and characterize the burn toxin responsible for late mortality and morbidity.
    • To explore the toxin's role in sepsis and its potential for immunotherapy.

    Main Methods:

    • Longitudinal research program spanning two decades.
    • Isolation and characterization of a novel burn toxin.
    • In vitro and in vivo studies on toxin's effects on sepsis.
    • Development of active and passive immunization strategies.

    Main Results:

    • Successful isolation of a burn toxin derived from thermal polymerization of lipoproteins.
    • Demonstrated influence of the burn toxin on sepsis outcomes.
    • Development of promising active and passive immunization therapies for severe burns.

    Conclusions:

    • The identified burn toxin is a key factor in late mortality and morbidity post-burn.
    • Immunization strategies targeting this toxin show potential for treating severe burns.
    • Further research into burn toxin mechanisms can advance burn care and sepsis management.

    Related Experiment Videos