Uromucoid excretion in normal individuals and stone formers

A quantitative immunological determination of uromucoid according to Laurell's method has been established. The average excretion rate of this glycoprotein in normal individuals was found to be 51.1 +/- 5 mg/24 hours. The uromucoid excretion in patients with calcium-oxalate, calcium-phosphate and cystine stones showed no significant change. In patients with urate stones and those with renal tubular acidosis a significant decrease in uromucoid excretion was found. Localization of uromucoid was found to be in the cells of the distal tubular section and the collecting tubules which was verified by immunincubation with FITC conjugated antihumanuromucoid globuline.