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Adenomatous and carcinomatous changes within hyperplastic colonic epithelium
Diseases of the Colon and Rectum
|April 1, 1979
Summary
Hyperplastic polyps are typically benign and do not cause colon cancer. However, this case shows hyperplastic polyps can transform into adenomas and develop into cancer, challenging the traditional polyp-cancer sequence understanding.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Oncology
Background:
- Hyperplastic polyps are generally considered benign, nonneoplastic colonic lesions.
- Unlike adenomatous polyps (tubular and villous), hyperplastic polyps are not traditionally associated with an increased risk of colorectal cancer.
- The established polyp-cancer sequence typically involves adenomatous transformation.