Related Experiment Video

Updated: Jul 19, 2026

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

The effect of chenodeoxycholic acid (CDCA) on cholesterol absorption

M Ponz de Leon, N Carulli, P Loria

    Gastroenterology
    |August 1, 1979
    PubMed
    Summary

    Chenodeoxycholic acid (CDCA) treatment significantly reduces dietary cholesterol absorption in humans. This finding suggests CDCA may aid gallstone dissolution by lowering cholesterol levels.

    More Related Videos

    Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans11:07

    Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

    Published on: December 19, 2014

    The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion06:14

    The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

    Published on: November 30, 2022

    Related Concept Videos

    Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

    Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

    Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
    Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
    Drug Absorption: Factors Affecting GI Absorption01:19

    Drug Absorption: Factors Affecting GI Absorption

    The process of oral drug absorption can be influenced by several factors. Weakly acidic drugs tend to be absorbed more readily from the stomach due to their nonionized state. However, absorption may be less efficient in the upper intestine, where drugs are often ionized. Interestingly, despite the stomach's apparent advantage for drug absorption, its mucous layer can hinder diffusion. Its surface area is also smaller than the intestine's, which can further slow down the absorption rate.
    In...
    Lipid Absorption01:24

    Lipid Absorption

    Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
    These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
    Factors Influencing Drug Absorption: Anatomical Parameters01:23

    Factors Influencing Drug Absorption: Anatomical Parameters

    Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
    Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

    Factors Influencing Drug Absorption: Disease States and Pharmacology

    Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
    Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
    Methods for Studying Drug Absorption: In vitro01:16

    Methods for Studying Drug Absorption: In vitro

    In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
    The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...