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Related Experiment Videos

Corneal staining subsequent to sequential fluorescein instillations.

D R Korb, J P Herman

    Journal of the American Optometric Association
    |March 1, 1979
    PubMed
    Summary
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    Fluorescein dye can cause corneal staining, especially with repeated use. Lid margin staining was most common, and severe staining may indicate contact lens intolerance.

    Area of Science:

    • Ophthalmology
    • Corneal Physiology
    • Ocular Diagnostics

    Background:

    • Fluorescein dye is commonly used in ophthalmology for diagnostic purposes.
    • Understanding the potential side effects of fluorescein, such as corneal staining, is crucial for accurate diagnosis and patient management.

    Purpose of the Study:

    • To investigate the incidence and patterns of corneal staining following fluorescein dye instillation.
    • To determine the clinical significance of fluorescein-induced corneal staining, particularly in relation to contact lens wear.

    Main Methods:

    • Liquid fluorescein (2%) was instilled into the inferior cul-de-sac.
    • Corneal and tear film observations were performed using a specialized examination routine.
    • Sequential fluorescein instillations were conducted at five-minute intervals for six additional times on 200 corneas.

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    Main Results:

    • The initial fluorescein instillation resulted in corneal staining in 19% of corneas.
    • An additional 23% of corneas exhibited staining after sequential instillations.
    • The most frequent type of staining was associated with the lid margins.
    • Severe staining showed a correlation with contact lens intolerance.

    Conclusions:

    • Fluorescein instillation can lead to corneal staining, with higher incidence after repeated applications.
    • Lid margin staining is the most common form observed.
    • Severe corneal staining may be a significant clinical indicator, potentially predicting contact lens intolerance.