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Malignant potential of keratoacanthoma.

R B Butcher

    The Laryngoscope
    |July 1, 1979
    PubMed
    Summary

    Keratoacanthoma, often seen as benign, can possess malignant potential or indicate underlying carcinoma. Recurrence after removal warrants investigation for malignancy.

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    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Keratoacanthoma is typically characterized as a benign skin lesion known for rapid initial growth and subsequent spontaneous regression.
    • The potential for keratoacanthoma to exhibit malignant characteristics or be associated with squamous cell carcinoma is not widely recognized.

    Observation:

    • This study presents four cases from Ochsner Medical Institutions where keratoacanthoma was associated with an underlying malignancy.
    • These cases highlight the importance of considering malignancy when a keratoacanthoma recurs post-excision.

    Findings:

    • Recurrent keratoacanthoma after surgical excision is a critical indicator that necessitates a thorough evaluation for an underlying malignant process.
    • The association between keratoacanthoma and carcinoma underscores the need for vigilance in diagnosing and managing these cutaneous lesions.

    Implications:

    • Clinicians should maintain a high index of suspicion for malignancy in cases of recurrent keratoacanthoma.
    • Further research into the biological mechanisms underlying the malignant potential of keratoacanthoma is warranted to improve diagnostic and therapeutic strategies.

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