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Effect of atenolol in angina pectoris of effort
Insights
Atenolol, a cardioselective beta-blocker, effectively prevents angina pectoris by reducing heart rate, blood pressure, and ST segment depression. It is particularly beneficial for patients with co-existing arterial hypertension.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Angina of effort is a common condition requiring effective management.
- Cardioselective beta-adrenoreceptor antagonists represent a class of drugs used for cardiovascular conditions.
Purpose of the Study:
- To evaluate the efficacy of atenolol, a cardioselective beta-blocker, in patients experiencing angina of effort.
- To assess the impact of atenolol on exercise tolerance and cardiovascular parameters.
Main Methods:
- A double-blind trial was conducted involving 11 patients diagnosed with angina of effort.
- Monitored exercise tolerance tests were performed to assess the drug's effects.
- Key cardiovascular parameters including heart rate, blood pressure, and ST segment depression were measured.
Main Results:
- Atenolol significantly reduced heart rate, blood pressure, and the time-tension index.
- ST segment depression, an indicator of myocardial ischemia, diminished following atenolol treatment.
- While working capacity showed an increase post-atenolol, no significant difference was noted compared to placebo, suggesting exercise tolerance adaptation.
Conclusions:
- Atenolol demonstrates utility in preventing angina pectoris.
- The drug is especially valuable for patients with angina of effort and concurrent arterial hypertension.
Abstract:
The effect of atenolol, a new cardioselective beta-adrenogenic blocking agent, was studied in 11 patients with angina of effort in a double-bind trial involving monitored exercise tolerance tests. The drug significantly reduced the heart rate, blood pressure and time-tension index. As a result, ST segment depression also diminished after treatment. Although working capacity, compared with controls, increased after atenolol, no difference was observed in this respect between the drug and placebo, suggesting the development of physiological tolerance to exercise. It is concluded that atenolol is useful in the prevention of angina pectoris, particularly in patients in whom there is associated arterial hypertension.