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Control of daughter-cell number variation in multiple fission: genetic versus environmental determinants in
Abstract:
Prototheca zopfii has been developed as an experimental system for studying the control of cytokinesis and daughter-cell number variation in multiple fission. Although mean daughter-cell number increases linearly with growth rate, and this dependency is genetically controlled, pedigree analysis shows that daughter-cell number variation is not under direct genetic control. In a population growing in steady-state balanced growth, each cell has a given probability of dividing into 2, 4, 8 16, or 32 daughter-cells. These probabilities are independent of the division number of the cell in the preceding generation, and can be altered by changes in the culture medium.