Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migration enhancement factor: a new lymphokine.

R H Weisbart, R Bluestone, L S Goldberg

    Proceedings of the National Academy of Sciences of the United States of America
    |March 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structure-specific amyloid precipitation in biofluids.

    Nature chemistry·2022
    Same author

    Passive transfer of allergic encephalomyelitis in rats: a tool for drug mechanism studies and detecting late-acting immunosuppressants.

    Inflammopharmacology·2019
    Same author

    Rheumatoid variants.

    Postgraduate medicine·2016
    Same author

    Cord blood immune biomarkers in small for gestational age births.

    Journal of developmental origins of health and disease·2014
    Same author

    The effect of some adenosine compounds in pruritus.

    The Lahey Clinic bulletin·2014
    Same author

    Computers in Cognitive Rehabilitation and Academic ReintegrationRedefining the Role After Brain Injury.

    Work (Reading, Mass.)·2014
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Researchers discovered a new lymphokine, migration enhancement factor, that opposes migration inhibitory factor. This factor, found in lymphocyte supernatants, enhances cell migration and has distinct properties from migration inhibitory factor.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Lymphocytes produce migration inhibitory factor (MIF) in response to antigens.
    • MIF is crucial for regulating leukocyte migration in immune responses.

    Purpose of the Study:

    • To investigate the temporal production of MIF by lymphocytes over a 7-day period.
    • To characterize any factors present in lymphocyte supernatants that modulate leukocyte migration.

    Main Methods:

    • Lymphocyte cultures were exposed to antigen for 7 days.
    • Migration inhibitory factor (MIF) and enhancement activity were measured using an agarose gel method with buffycoat leukocytes.
    • Polyacrylamide gel electrophoresis (PAGE) was used to analyze the properties of the factors.

    Main Results:

    Related Experiment Videos

    • Lymphocyte supernatants from 7-day cultures consistently exhibited MIF activity.
    • Supernatants from 2- to 5-day cultures frequently showed migration enhancement activity.
    • Enhancement activity was found in the beta-globulin region, distinct from MIF in the albumin fraction.
    • The enhancement activity was heat-stable and nondialyzable.

    Conclusions:

    • A novel lymphokine, termed migration enhancement factor (MEF), was identified.
    • MEF opposes the action of MIF, suggesting a complex regulatory mechanism for leukocyte migration.
    • These findings expand our understanding of lymphokine function in immune regulation.