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Plasma changes in endotoxin and anaphylactic shock (ATP, ADP and Creatine phosphorus)
Annals of Clinical and Laboratory Science
|March 1, 1979
Summary
Plasma adenosine 5' triphosphate (ATP) levels indicate metabolic state during shock. Low ATP correlates with critical conditions, while rising ATP signals recovery, offering a key biomarker for shock management.
Area of Science:
- Biochemistry
- Physiology
- Pathology
Background:
- Plasma adenosine 5' triphosphate (ATP) levels exhibit distinct patterns during endotoxin and anaphylactic shock.
- These patterns correlate with physiological parameters like platelet counts, arterial pressure, and electrocardiograms.
Purpose of the Study:
- To investigate plasma adenosine 5' triphosphate (ATP) and creatine phosphate (CP) levels as indicators of metabolic state in endotoxin and anaphylactic shock.
- To explore the relationship between plasma adenosine diphosphate (ADP) levels and shock severity/survival.
Main Methods:
- Measurement of plasma ATP, CP, and ADP levels in animal models of endotoxin and anaphylactic shock.
- Correlation analysis of plasma metabolite levels with physiological parameters (platelet count, arterial pressure, ECG) and survival time.
Main Results:
- Plasma ATP levels were low during shock episodes and rose with recovery, indicating ATP as a metabolic index.
- Plasma CP levels decreased in anaphylactic shock but significantly increased in endotoxin shock, suggesting tissue mobilization or cell damage.
- Elevated initial plasma ADP levels were associated with more severe anaphylactic reactions and shorter survival in endotoxin shock.
Conclusions:
- Plasma ATP serves as a reliable biomarker for metabolic status and recovery during shock.
- Distinct alterations in plasma CP and ADP levels provide further insights into shock pathophysiology and prognosis.