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Outpatient treatment trial of mild and severe hypertension

K L Stuart, C MacIver, J A Nicholson

    British Medical Journal
    |April 1, 1972
    PubMed

    Insights

    Treating mild hypertension is feasible and offers advantages. This study found active drug treatment effectively controlled blood pressure in both mild and severe hypertension cases.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Clinical Trials

    Background:

    • Limited data exists on the feasibility and benefits of treating mild hypertension.
    • Outpatient management of hypertension presents ongoing challenges.

    Purpose of the Study:

    • To evaluate the feasibility and effectiveness of treating mild hypertension.
    • To assess blood pressure control in mild, moderate, and severe hypertension using specific drugs.

    Main Methods:

    • A controlled trial involving 56 subjects with mild hypertension (26 active drug, 30 placebo).
    • A treatment program for 81 patients with moderate/severe hypertension receiving active drug.
    • Follow-up of 12 months or more for 87% (mild) and 80% (severe) hypertension groups.
    • Drugs used: bethanidine, debrisoquine, and guanethidine.

    Main Results:

    • Significant prevalence of cardiac enlargement (45%) and left ventricular hypertrophy (51%) in mild hypertension subjects.
    • Rapid blood pressure increases observed in placebo-treated mild hypertension patients.
    • Good blood pressure control achieved in 61% (63/104) of patients on active drugs across all severity groups.
    • Bethanidine, debrisoquine, and guanethidine demonstrated comparable effectiveness.

    Conclusions:

    • Treatment of mild hypertension is feasible and indicated, given associated cardiac abnormalities.
    • Active drug therapy provides effective blood pressure control in both mild and severe hypertension.
    • The studied antihypertensive drugs are similarly effective for blood pressure management.

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