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Subungual malignant melanoma.

|May 1, 1979

Summary

A Peutz-Jeghers syndrome patient developed subungual malignant melanoma on her finger, initially misdiagnosed as a nevus. Early detection and surgical amputation were crucial for successful treatment.

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Area of Science:

Oncology
Dermatology
Genetics

Background:

Peutz-Jeghers syndrome is a rare genetic disorder associated with an increased risk of various cancers.
Nail involvement in Peutz-Jeghers syndrome can manifest as hyperpigmentation, which may obscure other pathologies.

Observation:

A 60-year-old woman with Peutz-Jeghers syndrome presented with hyperpigmentation of the right index finger's terminal phalanx and nail.
Previous biopsies of the fingertip were diagnosed as junctional nevus.

Findings:

The final diagnosis after fingertip amputation was subungual malignant melanoma.
Subungual melanoma can mimic benign conditions like nevi, especially in the context of underlying genetic syndromes.

Implications:

This case highlights the importance of considering rare diagnoses in patients with genetic predispositions.
Thorough histopathological examination is critical for accurate diagnosis, even with prior benign interpretations.
Prompt surgical intervention is essential for managing subungual melanoma to prevent metastasis.

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