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Immunoglobulin A: site and sequence of expression in developing chicks.
Science (New York, N.Y.)
|January 26, 1973
Summary
Embryonic treatment preventing immunoglobulin M (IgM) and adult bursectomy stops IgA, IgG, and IgM synthesis in chickens. IgA-producing cells develop later, outside the bursa, unlike IgM and IgG cells.
Area of Science:
- Immunology
- Developmental Biology
- Avian Biology
Background:
- The bursa of Fabricius is critical for immunoglobulin synthesis in chickens.
- Different immunoglobulin classes (IgA, IgG, IgM) have distinct developmental timelines and origins.
Purpose of the Study:
- To investigate the effects of embryonic anti-IgM antibody treatment and bursectomy on immunoglobulin synthesis in chickens.
- To determine the developmental seeding of IgA-producing cells in relation to IgM and IgG-producing cells.
Main Methods:
- Embryonic treatment of chickens with heterologous antibodies to IgM.
- Surgical bursectomy at hatching.
- Analysis of immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) synthesis.
Main Results:
- Combined embryonic anti-IgM treatment and bursectomy completely prevented IgA, IgG, and IgM synthesis.
- IgA-producing cells are seeded later from the bursa compared to IgM and IgG-producing cells.
- IgM and IgG-producing cells do not differentiate into IgA producers outside the bursa.
Conclusions:
- The bursa of Fabricius is essential for the development of all major immunoglobulin classes in chickens.
- The distinct seeding times of B cell precursors influence the developmental capacity for different immunoglobulin classes.