[Dynamics of peripheral nerve procoagulant and fibrinolytic activity upon electrical stimulation]

The amount of procoagulative and fibrinolytic agents in cellular organoids was studied in the cat n. ischiadicus. All cellular fractions revealed high thromboplastic activity. Plasminogen, its activator, and proactivator were discovered in the ischiadic nerve. In dogs, the changes of functional state of nerves were accompanied by discharging of tissue thromboplastin and stimulators of fibrinolysis into the external medium with stimulaneous changes of intracellular contents of hemocoagulating factors. Thus, electric stimulation of the nerve intensified its thromboplastic activity, increased concentration of analogs of the plasma factors (II, VII, IX) and stimulation of fibrinolytic agents. The data obtained suggest presence of close enough interaction between the changes of functional condition of cells and dynamics of their procoagulative and fibrinolytic power.