The thrombogenicity of 6-azouridine

Area of Science:

• Biochemistry
• Pharmacology
• Thrombosis Research

Background:

• 6-Azauridine is an antimetabolite inhibiting de novo pyrimidine synthesis.
• Elevated homocystine levels and thromboembolic events were observed in patients treated with 6-azauridine.
• 6-Azauridine was withdrawn from psoriasis treatment due to thrombosis risks.

Purpose of the Study:

• To investigate the pro-thrombotic effects of 6-azauridine.
• To determine if 6-azauridine causes thrombosis independently of homocystinemia.

Main Methods:

• Utilized a standard animal model for thrombosis.
• Administered 6-azauridine orally and intravenously.

Main Results:

• 6-Azauridine induced both arterial and venous thrombosis in the animal model.
• Thrombosis occurred without a concurrent increase in serum homocystine levels.

Conclusions:

• 6-Azauridine possesses intrinsic pro-thrombotic properties.
• The mechanism of 6-azauridine-induced thrombosis may not solely rely on elevated homocystine levels.