Complement activation by rat platelets: its significance to inflammation in the rat
International Archives of Allergy and Applied Immunology
|January 1, 1979
Summary
Platelets generate chemotactic activity in rat plasma and serum. This activity requires an intact complement system and is not inhibited by soya bean trypsin inhibitor, suggesting a role for platelets in inflammation.
Area of Science:
- Immunology
- Hematology
Background:
- Platelets play a role in inflammation.
- Chemotactic factors attract immune cells to sites of inflammation.
Purpose of the Study:
- To investigate the generation of chemotactic activity by rat platelets.
- To explore the role of the complement system and protease inhibitors in this process.
Main Methods:
- Rat plasma and serum were incubated with aggregated or lysed rat platelets.
- Chemotactic activity was measured.
- Experiments were conducted with and without an intact complement system and with soya bean trypsin inhibitor.
Main Results:
- Aggregated or lysed rat platelets generated chemotactic activity in plasma and serum.
- This activity was dependent on an intact complement system.
- Soya bean trypsin inhibitor did not inhibit the chemotactic activity generated by platelet lysate.
Conclusions:
- Rat platelets can generate chemotactic activity.
- The complement system is essential for this generation.
- These findings support the role of platelets in inflammatory processes.
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