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Intermittent flow in tendon capillary bundles.

B A Hills

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |April 1, 1979
    PubMed
    Summary
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    Bullfrog and guinea pig Achilles tendons exhibit slow, synchronized capillary bundle opening and closing, impacting nutrient exchange models and potentially causing decompression injury.

    Area of Science:

    • Physiology
    • Vascular Biology
    • Connective Tissue

    Background:

    • Capillary perfusion dynamics are crucial for nutrient and gas exchange.
    • Previous models often assume continuous blood flow, potentially oversimplifying tissue perfusion.

    Purpose of the Study:

    • To investigate capillary perfusion patterns in the Achilles tendon.
    • To identify novel perfusion phenomena and their physiological implications.

    Main Methods:

    • Direct observation of capillary beds in bullfrog and guinea pig Achilles tendons.
    • Monitoring perfusion over extended periods (up to 2 hours).

    Main Results:

    • Observed slower capillary "flickering" than in skeletal muscle, consistent with lower tendon metabolic rates.

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  • Identified a novel "bundle phenomenon" where large capillary bundles (20-147 vessels) open and close synchronously.
  • Periods of no flow in these bundles averaged 39-43 minutes, with some bundles remaining closed for over 100 minutes.

    • Conclusions:

    • The bundle phenomenon significantly challenges existing mathematical models of blood perfusion and nutrient/gas exchange.
    • Time-averaging assumptions in perfusion rate determination may lead to significant errors.
    • The bundle phenomenon may play a role in decompression-induced tissue injury.