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Evidence for fetal antigen in human sarcoma.
Science (New York, N.Y.)
|August 3, 1973
Summary
A common antigen, S(2), is found in various tumors, not just sarcomas. Its presence suggests a potential link between fetal antigens, tumor development, and cellular changes preceding malignancy.
Area of Science:
- Oncology
- Immunology
- Biochemistry
Background:
- A specific antigen, S(2), was initially identified as sarcoma-associated.
- Recent findings indicate S(2) is present in a broader range of human tumors.
Purpose of the Study:
- To investigate the distribution of the S(2) antigen in various tumor types.
- To explore the potential origin and implications of S(2) antigen presence in cancer patients.
Main Methods:
- Immunological assays to detect the S(2) antigen.
- Absorption studies using human embryonic tissues.
- Serological analysis of patients with tumors and their relatives.
Main Results:
- The S(2) antigen is widely distributed across different types of human tumors.
- Absorption studies suggest S(2) may function as a fetal antigen.
- Antibodies to S(2) are detected in tumor patients and their relatives.
Conclusions:
- The S(2) antigen is not exclusive to sarcomas but is a common marker in various malignancies.
- S(2) antigen's fetal nature and presence in relatives may indicate a predisposition to cellular dedifferentiation and malignant transformation.