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Published on: January 2, 2017
High volume antisera yields from rabbits using plasmapheresis
Journal of Immunological Methods
|May 10, 1979
Summary
A straightforward plasmapheresis technique for rabbits allows weekly collection of 75 ml antisera. Antibody titers remained stable during these intervals, validating the procedure for consistent antiserum production.
Area of Science:
- Immunology
- Veterinary Medicine
- Laboratory Animal Science
Background:
- Antibody production in rabbits is crucial for various research applications.
- Efficient and repeatable methods for antiserum collection are needed.
- Plasmapheresis offers a potential solution for large-scale antibody harvesting.
Purpose of the Study:
- To describe a simple plasmapheresis procedure for rabbits.
- To evaluate the feasibility of weekly antisera collection.
- To assess antibody titer stability over time.
Main Methods:
- A simplified plasmapheresis protocol was developed for rabbits.
- Approximately 75 ml of antisera was collected weekly.
- Antibody titers were monitored throughout the collection period.
Main Results:
- The described procedure enabled consistent weekly collection of rabbit antisera.
- Significant antibody titer levels were maintained across weekly intervals.
- The method proved effective for sustained antisera yield.
Conclusions:
- The developed plasmapheresis technique is a simple and effective method for obtaining rabbit antisera.
- This procedure supports regular antibody harvesting without compromising titer.
- It provides a reliable source of antisera for research purposes.
