Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conductivity and hardness changes in aged compacts.

R P Bhatia, N G Lordi

    Journal of Pharmaceutical Sciences
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Indirect evaluation of corneal apoptosis in contact lens wearers by estimation of nitric oxide and antioxidant enzymes in tears.

    Oman journal of ophthalmology·2011
    Same author

    Limbal stem cell study in contact lens wearers.

    Annals of ophthalmology (Skokie, Ill.)·2009
    Same author

    Role of malondialdehyde and superoxide dismutase in cataractogenesis.

    Annals of ophthalmology (Skokie, Ill.)·2007
    Same author

    Corneal and conjunctival impression cytology in soft contact lens wearers.

    Annals of ophthalmology (Skokie, Ill.)·2007
    Same author

    Are high-water-content contact lenses safe?

    Annals of ophthalmology (Skokie, Ill.)·2007
    Same author

    Dielectric characterization of thermodynamic first order events in model frozen systems intended for lyophilization.

    PDA journal of pharmaceutical science and technology·1995
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Tablet hardness and electrical conductance were significantly affected by humidity. High humidity (76%) stabilized salt tablets, while low humidity (20%) increased hardness and decreased conductance in salt and lactose tablets.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Tablet properties are crucial for drug delivery and stability.
    • Environmental factors like humidity can significantly impact tablet physical characteristics.
    • Understanding these impacts is essential for formulation development and storage recommendations.

    Purpose of the Study:

    • To investigate the effects of relative humidity on the physical properties of salt and lactose tablets.
    • To determine how electrical resistance and hardness change over time under different humidity conditions.

    Main Methods:

    • Tablets of sodium chloride, potassium chloride, ammonium chloride, and spray-dried lactose were prepared.
    • Tablets were stored at controlled relative humidity levels (20% and 76%).
    • Electrical resistance and tablet hardness were measured at intervals over 45 days.

    Related Experiment Videos

    Main Results:

    • Salt tablets stored at 20% relative humidity showed a 70-200% increase in hardness and a 10-fold decrease in conductance over 45 days.
    • At 76% relative humidity, salt tablets exhibited stable or slightly decreased hardness with slight increases in conductance.
    • Lactose tablets showed a slight decrease in hardness and a corresponding increase in conductance under both humidity conditions.

    Conclusions:

    • Relative humidity plays a critical role in the physical stability of pharmaceutical tablets.
    • Low humidity can lead to increased hardness and decreased conductivity in salt-based tablets.
    • High humidity appears to stabilize salt tablets, while lactose tablets are less affected by humidity changes in terms of hardness and conductance.