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[Multiple conjunctival malignant melanomas (author's transl)].

R Haddad

    Klinische Monatsblatter Fur Augenheilkunde
    |April 1, 1979
    PubMed
    Summary
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    A patient with conjunctival melanoma developed a second, nonpigmented melanoma on the eyelid margin years later. Histopathology suggests the second melanoma originated from a non-pigmented nevus, not acquired melanosis.

    Area of Science:

    • Ophthalmology
    • Dermatology
    • Oncology

    Background:

    • Malignant melanoma can arise in ocular and periocular structures.
    • Recurrence or new primary melanomas can occur after initial treatment.

    Observation:

    • A 42-year-old male with a history of excised conjunctival malignant melanoma presented with a new nonpigmented mass on the eyelid margin.
    • The initial melanoma was pigmented and appeared to arise from a conjunctival nevus.

    Findings:

    • The new eyelid margin mass was diagnosed as malignant melanoma.
    • Histopathological analysis indicated the second melanoma likely originated from a non-pigmented compound nevus.
    • Acquired melanosis sine pigmento was considered but deemed less likely.

    Implications:

    Related Experiment Videos

    • This case highlights the possibility of secondary, non-pigmented melanomas arising from nevi in the periocular region.
    • It underscores the importance of long-term surveillance for patients with a history of ocular or periocular melanoma.
    • Non-pigmented melanomas, even in the presence of prior pigmented lesions, require careful histopathological evaluation.