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The kidney and intravascular coagulation in myelomatosis
Abstract:
In 15 out of 35 patients with myelomatosis histological examination showed intravascular fibrin within the glomeruli, and this was associated with proliferation of the mesangial complex in 12. The presence of intravascular fibrin and mesangial proliferation was not associated with any specific immunoglobulin abnormality or with the presence or absence of Bence Jones proteinuria. In addition to fibrin being present within glomerular capillaries it was also shown in intertubular capillaries in three cases of myelomatosis with acute tubular necrosis. It is suggested that intraglomerular coagulation and fibrin deposition may contribute to the genesis of renal failure in myelomatosis.
Insights
Intravascular fibrin deposits in the glomeruli were observed in myelomatosis patients, potentially contributing to kidney failure. This finding was linked to mesangial proliferation but not specific immunoglobulin issues.
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Multiple myeloma (myelomatosis) can lead to kidney complications.
- Renal failure is a significant concern in patients with multiple myeloma.
Purpose of the Study:
- To investigate the presence and significance of intravascular fibrin deposition in the kidneys of patients with myelomatosis.
- To correlate fibrin deposition with histological findings and clinical features.
Main Methods:
- Histological examination of renal tissue from 35 patients with myelomatosis.
- Analysis of glomerular and intertubular capillaries for fibrin.
- Correlation with immunoglobulin abnormalities and Bence Jones proteinuria.
Main Results:
- Intravascular fibrin was found in the glomeruli of 15 out of 35 patients.
- Mesangial complex proliferation was observed in 12 of these patients.
- Fibrin deposition was not associated with specific immunoglobulin abnormalities or Bence Jones proteinuria.
- Fibrin was also present in intertubular capillaries in three cases with acute tubular necrosis.
Conclusions:
- Intraglomerular coagulation and fibrin deposition may play a role in the development of renal failure in myelomatosis.
- These findings highlight a potential mechanism for kidney damage in multiple myeloma.