Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selection for high mutation rates in chemostats.

E C Cox, T C Gibson

    Genetics
    |June 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Mutator populations of Escherichia coli exhibit higher fitness in chemostat competition experiments due to the emergence of beneficial mutations. This increased fitness is linked to population density fluctuations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Meeting the Calls of Necessity.

    The American journal of dental science·2019
    Same author

    EPIDEMIOLOGY OF CARDIOVASCULAR DISEASE. CARDIAC FAILURE.

    A listing of research in the cardiovascular field·2014
    Same author

    COMMUNITY SERVICES FOR CONGESTIVE HEART FAILURE.

    A listing of research in the cardiovascular field·2014
    Same author

    Impact of assisted reproductive technologies: a mitochondrial perspective of cytoplasmic transplantation.

    Current topics in developmental biology·2007
    Same author

    Mitochondrial DNA deletions in primate embryonic and adult stem cells.

    Reproductive biomedicine online·2006
    Same author

    Mitochondrial DNA deletions in rhesus macaque oocytes and embryos.

    Molecular human reproduction·2005
    Same journal

    Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

    Genetics·2026
    Same journal

    Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

    Genetics·2026
    Same journal

    Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

    Genetics·2026
    Same journal

    Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

    Genetics·2026
    Same journal

    Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

    Genetics·2026
    Same journal

    Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

    Genetics·2026
    See all related articles

    Area of Science:

    • Microbial evolution
    • Population genetics
    • Bacterial adaptation

    Background:

    • Mutator strains accelerate evolution by increasing mutation rates.
    • Understanding adaptation in controlled environments like chemostats is crucial for evolutionary biology.

    Purpose of the Study:

    • To investigate the fitness advantage of mutator populations of Escherichia coli in chemostat competition.
    • To determine the factors contributing to the observed fitness differences.

    Main Methods:

    • Competition experiments were conducted in chemostats using mutator and wild-type Escherichia coli.
    • Fitness was quantified by comparing population growth rates.
    • Correlation analysis was performed between fitness values and population density fluctuations.

    Related Experiment Videos

    Main Results:

    • Mutator populations demonstrated significantly higher fitness compared to wild-type populations.
    • The increased fitness of mutators was attributed to the rapid acquisition of adaptive mutations.
    • Fitness values showed a strong positive correlation with population density fluctuations across different chemostats.

    Conclusions:

    • Mutator genotypes provide a fitness benefit in Escherichia coli adapting to chemostat environments.
    • Adaptive mutation and population dynamics are key drivers of fitness variation in evolving microbial populations.