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Related Experiment Videos

Lymph node pathology in Trypanosoma brucei-infected sheep.

P R Barrowman, J A Roos

    The Onderstepoort Journal of Veterinary Research
    |March 1, 1979
    PubMed
    Summary

    Sheep infected with Trypanosoma brucei showed significant lymph node changes. Initially, lymphoid stimulation was replaced by reticulo-endothelial cell proliferation, leading to lymph stasis and necrosis, ultimately causing lymphopenia.

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    Area of Science:

    • Veterinary Pathology
    • Immunology
    • Parasitology

    Background:

    • Trypanosoma brucei infection in sheep causes significant pathological changes.
    • Understanding lymph node morphology during infection is crucial for disease management.

    Purpose of the Study:

    • To investigate the temporal sequence of morphological alterations in sheep prefemoral lymph nodes during Trypanosoma brucei infection.

    Main Methods:

    • Histopathological examination of sheep prefemoral lymph nodes at weekly intervals post-infection.
    • Analysis of lymphoid and reticulo-endothelial cellular responses.

    Main Results:

    • Early lymphoid stimulation was superseded by reticulo-endothelial cell proliferation, leading to macrophage accumulation, vascular damage, and lymph stasis.
    • Subsequent lymphoid tissue proliferation involved active germinal centers and lymphoblast/plasmablast production.
    • Both reticulo-endothelial and lymphoid components showed increasing cellular necrosis throughout infection, correlating with lymphopenia, not lymphocytosis.

    Conclusions:

    • Trypanosoma brucei infection induces dynamic morphological changes in lymph nodes, characterized by initial lymphoid stimulation followed by reticulo-endothelial cell dominance and significant cellular necrosis.
    • The observed immune response primarily involves germinal center cells, contributing to lymph stasis and lymphopenia.

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