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Related Experiment Videos

Studies on brain-thymus cross-reactive antigens.

G Birnbaum

    Brain Research
    |January 24, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A novel brain-thymus antigen was identified in mice, present in adult brains but absent in newborns. This antigen differs from the theta antigen and is more concentrated in gray matter.

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    Area of Science:

    • Neuroimmunology
    • Developmental Biology
    • Immunochemistry

    Background:

    • The study investigates antigens shared between mouse brain and thymocytes.
    • Utilizes rabbit anti-mouse brain antiserum (RAMB) for antigen detection and characterization.

    Purpose of the Study:

    • To characterize a specific antigen(s) found in both mouse brain and thymocytes.
    • To determine the developmental expression pattern of this brain-thymus antigen.
    • To differentiate this antigen from the known theta antigen.

    Main Methods:

    • Antigen detection using rabbit anti-mouse brain antiserum (RAMB).
    • Developmental expression analysis in mouse brains from birth to adulthood.
    • Enzyme treatment (trypsin) to assess antigen accessibility.

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  • Cross-species reactivity testing (rat brain and thymocytes).
  • Differential concentration analysis between gray and white matter.
  • Cross-absorption studies with RAMB and anti-theta antiserum.

    • Main Results:

    • Brain-thymus antigen is present in adult mouse brains across various strains, including athymic mice, irrespective of theta antigen genotype.
    • Antigen is absent in newborn mouse brains, appearing gradually to reach adult levels by two weeks post-birth.
    • Trypsin treatment did not alter antigen levels. Antigens were found on rat thymocytes but not rat brain.
    • Gray matter exhibited 3- to 4-fold higher concentrations of brain-thymus antigens compared to white matter.
    • Cross-absorption studies indicated that brain-thymus antigen and theta antigen are distinct entities.

    Conclusions:

    • A novel brain-thymus antigen, distinct from theta antigen, is identified and characterized.
    • This antigen shows specific developmental regulation, appearing postnatally.
    • Its differential distribution in brain matter suggests specific functional roles in the central nervous system.