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[Immunoglobulins and dysglobulinemias. Introduction and general data]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|October 1, 1974
Summary
This review covers serum immunoglobulins in rheumatology, detailing their structure, biosynthesis, and B lymphocyte interactions. It clarifies terminology, preferring monoclonal immunoglobulin over dysglobulinaemia, and discusses related clinical conditions.
Area of Science:
- Immunology
- Rheumatology
Context:
- Review of current knowledge on serum immunoglobulins in rheumatology.
- Focus on structure, cellular biosynthesis, and B lymphocyte membrane immunoglobulin relations.
Purpose:
- To examine the concept of dysglobulinaemia.
- To advocate for preferred terminology: monoclonal immunoglobulin and monoclonal immunoglobulinopathy.
- To discuss clinical and immunochemical classifications and related conditions.
Summary:
- Discusses serum immunoglobulins, their B cell interactions, and the concept of dysglobulinaemia.
- Recommends 'monoclonal immunoglobulin' and 'monoclonal immunoglobulinopathy' over 'dysglobulinaemia' and 'paraprotein'.
- Covers classification, amyloidosis, plasmacytic dyscrasias, and cryoglobulins, with a brief look at pathogenesis.
Impact:
- Provides a clear framework for understanding immunoglobulin abnormalities in rheumatology.
- Enhances diagnostic clarity through preferred terminology.
- Offers insights into the pathogenesis of related immune-mediated conditions.