Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Splenectomy in chronic hepatitis with an autoimmune component].

D Burlui, C Constantinescu, C Dragoncea

    Revista De Chirurgie, Oncologie, Radiologie, O.R.L., Oftalmologie, Stomatologie. Chirurgie
    |March 1, 1979
    PubMed
    Summary

    Splenectomy significantly reduces anti-liver antibodies in autoimmune hepatitis patients, stabilizing lesions and improving outcomes. This procedure acts as an immunosuppressive therapy, potentially preventing cirrhosis progression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The association between endometrial polyps, chronic endometritis, and IVF outcomes.

    European review for medical and pharmacological sciences·2023
    Same author

    Vaccine hesitancy educational tools for healthcare providers and trainees: A scoping review.

    Vaccine·2022
    Same author

    Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network.

    The Pediatric infectious disease journal·2022
    Same author

    That dog won't fit: body size awareness in dogs.

    Animal cognition·2019
    Same author

    Correction to: Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation.

    Journal of neurology·2018
    Same author

    Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis.

    Biochimica et biophysica acta·2016

    Area of Science:

    • Immunology
    • Hepatology
    • Surgical Pathology

    Context:

    • Investigates the spleen's role in chronic active hepatitis with autoimmune features.
    • Focuses on 20 patients with histological diagnosis of chronic active/aggressive hepatitis and autoantibodies.
    • Examines immunological markers and clinical outcomes post-splenectomy.

    Purpose:

    • To evaluate the immunological and clinical effects of splenectomy in patients with autoimmune chronic active hepatitis.
    • To determine if splenectomy can halt the progression of liver disease and prevent cirrhosis.

    Summary:

    • Splenectomy led to a rapid decrease in spleen-produced anti-liver antibodies and later, IgM antibodies.
    • Histological liver lesions stabilized, and biological markers improved post-surgery.

    Related Experiment Videos

  • Patients exhibited good clinical evolution following the intervention.

    • Impact:

    • Splenectomy demonstrates potential as an immunosuppressive therapy for specific hepatopathies.
    • The procedure may arrest the progression of chronic hepatitis towards liver cirrhosis.
    • Highlights the spleen as a key organ in the autoimmune pathogenesis of chronic hepatitis.