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[Testosterone, epitestosterone and total estrogen excretion in men with cancer of certain localizations]
Abstract:
To obtain more insight into the problem on the concentration of active androgens in the male organism, the diurnal elimination of testosterone, epitestosterone and estrogens in the urine of male patients with cancer of the lung, urinary bladder, larynx and prostate (321 patients), in stage II--III, was estimated. In patients with cancer of the lung and urinary bladder testosterone was found to be lowered, while total estrogens--lowered or unchanged irrespective of age, a relative hyperestrogenization being noted in them. Contrary, in cancer of the larynx and prostate the male hormones were predominating over female ones (hyperandrogenization). In all the examined patients irrespective of the tumor process localization a relative or even absolute predominance of epitestosterone over testosterone was evident.
Insights
Hormone levels vary in male cancer patients. Lung and bladder cancers show lower testosterone and relative hyperestrogenization, while larynx and prostate cancers exhibit hyperandrogenization. Epitestosterone often predominates over testosterone.
Area of Science:
- Endocrinology
- Oncology
- Urology
Background:
- Altered androgen and estrogen concentrations are implicated in male cancers.
- Understanding hormonal shifts in various male malignancies is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate diurnal urinary elimination of testosterone, epitestosterone, and estrogens in male cancer patients.
- To correlate hormonal profiles with specific cancer types: lung, urinary bladder, larynx, and prostate.
Main Methods:
- Collected diurnal urine samples from 321 male patients (Stage II-III) with lung, bladder, larynx, or prostate cancer.
- Quantified urinary levels of testosterone, epitestosterone, and total estrogens.
- Analyzed hormonal profiles in relation to cancer type and patient age.
Main Results:
- Lung and bladder cancer patients showed decreased testosterone and variable estrogen levels, indicating relative hyperestrogenization.
- Larynx and prostate cancer patients exhibited hyperandrogenization, with male hormones predominating.
- A consistent finding across all cancer types was the relative or absolute predominance of epitestosterone over testosterone.
Conclusions:
- Hormonal imbalances, including altered androgen-estrogen ratios and epitestosterone/testosterone dynamics, are associated with male cancers.
- Specific hormonal profiles may correlate with different cancer localizations.
- Further research into these hormonal alterations could offer diagnostic or therapeutic insights.
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