[Clonogenic cell response of murine NK Ly/LL solid tumor to N-methyl-N-nitrosourea]

By the in vitro technic for obtaining clones of cells of murine solid tumor NKLy/LL it was demonstrated that clonogenic cells survival rate versus NNU dosage curve in the interval of 12.5--200.0 mg/kg is exponential and characterized by the dosage value D0 = 29.15 mg/kg. In large size tumors (15.0--17.0 g) which higher death rate of clonogenic cells was noted (the survived fraction approximately 0.5%) than in tumors weighing 1.0--7.0 g (the survived fraction--2--4%), that seems to be related to a greater sensitivity of resting tumor cells to MNU.