[Effect of diethylnitrosamine on the protein-synthesizing cell system of the rat liver]

Diethylnitrosoamine is found to alter the course of the regenerative processes induced by partial hepatectomy, which is manifested in essentially other, than in the control, changes of polyribosomes and mRNA. In early terms following DENA injection one may observe a reduced content of total polyribosomes, a sharp decrease in the amount of membrane-bound polyribosomes, the inhibited incorporation of newly produced mRNA in both classes of polyribosomes. In later terms, a proportion of the membrane-bound polyribosomes is again diminished, while the ratio of the specific radioactivity of free and membrane-bound polyribosomes is raised.