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Related Experiment Videos

Dysautonomia in mitral valve prolapse.

H C Coghlan, P Phares, M Cowley

    The American Journal of Medicine
    |August 1, 1979
    PubMed
    Summary

    Patients with mitral valve prolapse exhibit abnormal autonomic nervous system function, showing exaggerated heart rate changes during autonomic stress tests. This suggests impaired baroreflex control in these individuals.

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    Area of Science:

    • Cardiology
    • Autonomic Neuroscience

    Background:

    • Clinical features of mitral valve prolapse (MVP) are often linked to autonomic dysfunction.
    • Understanding autonomic responses in MVP is crucial for managing associated symptoms.

    Purpose of the Study:

    • To investigate heart rate and blood pressure responses to autonomic stress in patients with MVP.
    • To compare autonomic function in MVP patients versus healthy controls.

    Main Methods:

    • Utilized a standardized Valsalva maneuver and postural test.
    • Assessed 44 untreated patients with MVP and 15 healthy controls.
    • Monitored heart rate and blood pressure responses.

    Main Results:

    • MVP patients displayed similar directional blood pressure and heart rate changes as controls.
    • Patients showed significantly greater heart rate oscillations in upright posture.
    • Exaggerated and prolonged bradycardia was observed post-Valsalva and postural tests in MVP patients.
    • Increased respiratory variation of R-R intervals was noted in MVP patients, especially during postural changes.

    Conclusions:

    • Dysautonomic responses in symptomatic MVP patients suggest abnormal central modulation of baroreflexes.
    • Autonomic neural dysfunction plays a significant role in the clinical presentation of mitral valve prolapse.

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