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Related Experiment Videos

Cancer and scleroderma.

S C Duncan, R K Winkelmann

    Archives of Dermatology
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Scleroderma patients at Mayo Clinic showed similar cancer frequencies to the general population, with breast carcinoma being most common. Lymphoma-leukemia malignancies were notably frequent in this scleroderma patient cohort.

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    Area of Science:

    • Rheumatology
    • Oncology
    • Internal Medicine

    Background:

    • Scleroderma is an autoimmune disease with potential systemic manifestations.
    • The association between scleroderma and internal malignancies requires further clarification.
    • Previous studies suggested specific cancer types were more prevalent in scleroderma patients.

    Purpose of the Study:

    • To review the incidence and types of internal malignancies in patients with scleroderma.
    • To compare cancer frequencies in scleroderma patients with the general population.
    • To investigate the temporal relationship and outcomes of concurrent scleroderma and malignancy.

    Main Methods:

    • Retrospective review of 2,141 scleroderma patients seen at Mayo Clinic (1959-1975).
    • Analysis of 87 internal malignancies identified in 78 patients.

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  • Comparison of cancer types with general population frequencies.

    • Main Results:

    • The relative frequency of cancer types in scleroderma patients mirrored the general population.
    • Breast and uterine carcinomas were more common, consistent with female predominance in scleroderma.
    • Lymphoma-leukemia malignancies were the second most frequent (17%), and lung carcinoma was not the most common.
    • In 68% of cases, both conditions occurred within a three-year period, indicating a high-risk subgroup with significant mortality.

    Conclusions:

    • Scleroderma patients do not exhibit a significantly different cancer profile compared to the general population, apart from expected increases in female-related cancers.
    • Lymphoma-leukemia malignancies represent a significant concern in scleroderma patients.
    • The concurrent development of scleroderma and malignancy within a short timeframe is associated with poor prognosis.