Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catecholamines and convulsions.

S T Mason, M E Corcoran

    Brain Research
    |July 20, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Noradrenaline depletion potentiates seizures, while dopamine depletion does not. Cocaine-induced seizures occur via a non-specific toxic mechanism, independent of these neurotransmitters.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Regional changes in gene expression after limbic kindling.

    Cellular and molecular neurobiology·2011
    Same author

    The benefits of good nursing supervision in institutions for mental defectives.

    American journal of mental deficiency·2010
    Same author

    Psychiatric nursing.

    The American journal of psychiatry·2010
    Same author

    Observations and suggestions for improving the care of mental defectives.

    American journal of mental deficiency·2010
    Same author

    Psychiatric nursing.

    The American journal of psychiatry·2010
    Same author

    Amygdaloid kindling is anxiogenic but fails to alter object recognition or spatial working memory in rats.

    Epilepsy & behavior : E&B·2008
    Same journal

    IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

    Brain research·2026
    Same journal

    Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

    Brain research·2026
    Same journal

    Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

    Brain research·2026
    Same journal

    Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

    Brain research·2026
    Same journal

    Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

    Brain research·2026
    Same journal

    Emotions, the amygdala, and the right hemisphere.

    Brain research·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Neuropharmacology
    • Neurotoxicology

    Background:

    • Noradrenaline and dopamine are key neurotransmitters in the central nervous system.
    • Understanding their roles in seizure susceptibility is crucial for neurological research.

    Purpose of the Study:

    • To investigate the role of noradrenaline and dopamine depletion in seizure susceptibility.
    • To determine the mechanism of cocaine-induced seizures in relation to these catecholamines.

    Main Methods:

    • Rats underwent intracerebral injection of 6-hydroxydopamine to selectively deplete brain noradrenaline or dopamine.
    • Seizure susceptibility was assessed using Metrazol and electroconvulsive shock.
    • Cocaine was administered to evaluate its seizure-inducing effects in catecholamine-depleted rats.

    Related Experiment Videos

    Main Results:

    • Depletion of brain noradrenaline significantly potentiated seizures induced by Metrazol and electroconvulsive shock.
    • Depletion of brain dopamine did not alter seizure susceptibility to either stimulus.
    • Cocaine-induced seizures persisted in rats with severely depleted noradrenaline and dopamine levels.

    Conclusions:

    • Noradrenaline plays a significant role in reducing central nervous system susceptibility to various seizure-inducing stimuli.
    • Dopamine does not appear to be involved in modulating seizure threshold in this context.
    • Cocaine-induced seizures are mediated by a non-specific toxic mechanism, not directly by noradrenaline or dopamine pathways.