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Concentrations of ionic, total, and bound fluoride in plasma
Clinical Chemistry
|April 1, 1979
Summary
Plasma fluoride levels do not differ between sexes. However, older adults over 60 exhibit significantly higher ionic and total fluoride concentrations compared to younger individuals, indicating an age-related increase in fluoride accumulation.
Area of Science:
- Environmental Health
- Biochemistry
- Toxicology
Background:
- Fluoride is essential for dental health but can be toxic at high concentrations.
- Plasma fluoride levels can be influenced by various factors, including age and water fluoridation.
- Understanding fluoride pharmacokinetics is crucial for public health assessments.
Purpose of the Study:
- To investigate the influence of sex and age on plasma fluoride concentrations.
- To determine if living in a fluoridated community affects plasma fluoride levels.
- To analyze ionic, bound, and total fluoride concentrations in different age and sex groups.
Main Methods:
- Analysis of plasma samples from 264 fasting subjects.
- Measurement of ionic, bound, and total fluoride concentrations.
- Statistical comparison of fluoride levels across different age and sex groups.
Main Results:
- No significant sex-based differences in plasma fluoride concentrations were observed.
- Individuals over 60 years old showed significantly higher mean ionic and total fluoride levels.
- Bound fluoride concentration was lower in the 21-30 age group compared to older adults.
Conclusions:
- Age is a significant factor influencing plasma fluoride concentrations, with levels increasing in older adults.
- Sex does not appear to impact plasma fluoride levels in this fluoridated community.
- Further research may explore the long-term implications of age-related fluoride accumulation.