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Summary
Urinary tract abnormalities, including hydronephrosis and blood clots, are common in hemophilia patients, especially those with severe hematuria. Radiological exams revealed these issues in 36% of subjects studied.
Area of Science:
- Urology
- Hematology
- Radiology
Background:
- Hematuria, renal colic, and clot retention are known urinary tract complications in hemophilia.
- However, detailed radiological investigation of these changes remains limited.
Observation:
- Twenty-eight hemophilia patients underwent 59 radiological examinations, including 41 intravenous urograms (IVU).
- Abnormalities were detected in 36% of patients.
Findings:
- Six patients exhibited hydronephrosis, one had a non-functioning kidney, and two showed blood clots in the collecting system.
- Abnormalities correlated with clinically severe hematuria; mild cases were often normal.
- Hydronephrosis causes included extrinsic compression or intrinsic clot retention; some cases suggested organized hematoma with peri-ureteric fibrosis.
Implications:
- Radiological assessment is crucial for identifying urinary tract complications in hemophilia.
- Understanding the etiology of hydronephrosis aids in patient management.
- Further research into the long-term effects of urinary tract changes in hemophilia is warranted.