Kinetics of a rifampicin-trimethoprim combination

Two different regimens of a rifampicin-trimethoprim combination were studied in two groups of healthy volunteers. Each regimen was administered for seven consecutive days. In the first, the treatment consisted of 300 mg of rifampicin and 80 mg of trimethoprim administered t.i.d. In the second 450 mg of rifampicin and 120 mg of trimethoprim were administered b.i.d. Data on serum levels and urinary excretion are discussed.