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Isobaric gas counterdiffusion in rabbit eye.

J R Cowley, C J Lambertsen

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |July 1, 1979
    PubMed
    Summary
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    The superficial isobaric gas counterdiffusion phenomenon does not affect rabbit eyes, unlike their skin. This study found no ocular lesions or bubbles, even after prolonged exposure, suggesting eye structures are resistant to this gas embolism.

    Area of Science:

    • Physiology
    • Diving Medicine
    • Gas Physiology

    Background:

    • The superficial isobaric gas counterdiffusion phenomenon can cause dermal lesions and lethal gas embolism.
    • Understanding the effects of gas counterdiffusion on different tissues is crucial for safety in various environments.

    Purpose of the Study:

    • To investigate the effects of superficial isobaric gas counterdiffusion on the eye structures of New Zealand White rabbits.
    • To compare the ocular response to gas counterdiffusion with the known dermal effects.

    Main Methods:

    • New Zealand White rabbits were exposed to a nitrous oxide-oxygen (N2O-O2) mixture under normobaric and hyperbaric (2 ATA) conditions.
    • Animals were surrounded by a helium (He) environment to facilitate counterdiffusion.
    • Ocular tissues (conjunctiva, cornea, anterior chamber) and skin were examined for gas lesion and bubble formation.

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    Main Results:

    • No gas lesion formation was observed in the conjunctiva or cornea of any experimental animals.
    • No gas bubble formation occurred in the anterior compartment of the eye, even with maximal 8-hour exposures.
    • In contrast, the skin of the same animals exhibited progressive gas-filled lesions after 3 hours at 1 ATA.

    Conclusions:

    • Ocular structures in rabbits demonstrate significant resistance to superficial isobaric gas counterdiffusion.
    • The findings suggest that the eye is relatively insensitive to gas embolism formation compared to dermal tissues.
    • Further research is warranted to elucidate the specific physiological reasons for the eye's resilience to this phenomenon.