Increasing pre-excitation during exercise and isoproterenol infusion. Evidence for a catecholamine sensitive bypass...

A patient with atypical chest pain developed pre-excitation during exercise and isoproterenol infusion, with "ischemic" ST depression only during the pre-excited beats. Coronary angiography and myocardial lactate extraction showed no evidence of abnormal coronary vessels. Electrophysiologic study and pacing-induced tachycardia did not induce pre-excitation, whereas exercise induced progressive increase in pre-excitation. The data are consistent with an unusual form of pre-excitation, perhaps related to responsiveness of an accessory bypass tract to catecholamine stimulation. The data also show that the false positive exercise test in this syndrome is due to progressively increasing pre-excitation and therefore more abnormal repolarization.