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Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
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Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus

Published on: September 20, 2013

Fine structural evidence for hormone secretion by the human thymus

J M Vetters, R F Macadam

    Journal of Clinical Pathology
    |March 1, 1973
    PubMed

    The epithelial cells of the Hassall's corpuscles in 11 human thymus glands (nine cases of myasthenia gravis and two glands from patients undergoing surgical correction of congenital heart disease) have been examined by electron microscopy. In every instance the epithelial cells have the cytoplasmic organelle complex necessary for ;export'-type secretory activity and in addition contain large numbers of membrane-limited small spheroidal secretion granules.Hassall's corpuscles are avascular anatomical units and a pericorpuscular zone, at least 50 mum broad, is also without blood vessels. It is therefore suggested that the secretory product(s) of the corpuscular epithelial cells has a purely intrathymic function.

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